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Figure 4 | Molecular Cancer

Figure 4

From: Knock down of HIF-1α in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres

Figure 4

Profile of genes that are upregulated in response to hypoxia in GL261 control cells and show no change or downregulation in GL261 shHIF cells, using as normalization baseline the GL261 control cells in normoxia. For each cell line (control and shHIF) and condition: Norm (Normoxia) and Hyp (Hypoxia) we show the results from two independent experiments used in the analysis (R1 and R2). (A) Box plot analysis shows a five-number summary (the smallest observation, lower quartile, median, upper quartile, and largest observation) for the 149 significantly modulated Affymetrix Probe sets, found by Pavlidis Template Matching (p < 0.05), based on two individual experiments (R1 and R2). (B) Heat map showing the 149 Affymetrix probe sets including known HIF-1α targets that are upregulated in response to hypoxia in GL261 control cells and show no change or downregulation in GL261 shHIF cells. Red and blue colors denote increased and decreased mRNA abundance, respectively.

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Molecular Cancer

ISSN: 1476-4598