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Figure 3 | Molecular Cancer

Figure 3

From: Aurora-A down-regulates IkappaBα via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival

Figure 3

Cross-talk between Aur-A and PI3K pathway regulates VX-680 induced apoptosis in TSCC cells. Serum-starved Tca8113 cells treated with IGF-1 (I, 100 ng/ml), wortmannin (W, 1 μM), VX-680 (V, 5 nM) alone or in combination for 12 h. (a) Cells were subjected to Western blot analysis with indicated antibodies. GAPDH was used as a control. (b) The apoptosis was assessed by flow cytometry as a sub-G1 population. Images showed one representative of three independent experiments. Histogram represented the quantification.

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Molecular Cancer

ISSN: 1476-4598