Figure 3
From: CENPA overexpression promotes genome instability in pRb-depleted human cells
Chromosome mis-segregation in pRb-depleted cells. A) Time-lapse video-microscopy done in mitotic HCT116 cells expressing the H2B-GFP gene. Images showing that wild type cells normally progress in mitosis segregating chromosome in two daughter cells. B) RB-depleted cells showing metaphases with unaligned chromosomes that segregate incorrectly generating micronuclei (white arrow) or tripolar metaphases dividing into three daughter cells (red arrow).