Figure 2From: Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathwaysSorafenib induces apoptosis and inhibits anchorage independent cell growth of a representative OS cell line. DNA content (A) and apoptosis (B) analysis after 72 h treatments. Soft agar assays as described in "materials and methods" section (C).Back to article page