Figure 7

Survival of FSCCL-SCID mice is prolonged with the treatment of MI-319. (A) Treatment with MI-319 did not result in significant body weight changes (> 15%). Wn=mouse body weight at day (n); W4 = mouse body weight at day (4) when the administration of MI-319 was started. (B) H&E staining of mouse blood smear and sections of mouse brain, bone marrow, liver, and spleen. Arrows in the upper blood panel (untreated) point to lymphocytes, indicating lymphoma involvement. Lower brain panel (MI-319-treated) is an example of no involvement by lymphoma. Note the thin meningeal lining of the brain (between opposing arrows). In comparison, the upper panel (untreated) shows examples of involvement of the meninges by lymphoma. Note the expanded space between the opposing arrows indicative of lymphoma cell infiltration. For the bone marrow (femurs) sections, lower panel (MI-319-treated) shows examples of normal marrow and upper panel (untreated) shows examples of involvement by WSU-FSCCL (note the cavities filled with lymphocytes). (C) The survival percentage of untreated and MI-319-treated mice is plotted against days post FSCCL inoculation. The control animals have a median survival day of 51.6, whereas the treatment animals have a median survival day of over 66.0. n = 7 for control group, n = 6 for treatment group, p < 0.0001.