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Figure 1 | Molecular Cancer

Figure 1

From: Transcriptomic analysis of pathways regulated by toll-like receptor 4 in a murine model of chronic pulmonary inflammation and carcinogenesis

Figure 1

Gene expression that increased in the BALBLps-dmice compared to BALB mice following chronic BHT. Two methods of analysis, supervised and unsupervised, were used to determine the genes increased at 1 day following BHT. A. Cluster 3 identified using statistical (GeneSpring) analysis in chronic BHT-treated BALB and BALBLps-dmice over a time course (oil and 1 and 3 day following chronic BHT). Each vertical line represents one sample for each strain for an n = 3 (oil, BHT 1 day, BHT 3 day), indicated by the small horizontal black line above each treatment on the x-axis. B. Profile analysis (Spotfire) similar to that of cluster 3. Each vertical line represents one sample for each strain for an n = 3 (oil, BHT 1 day, BHT 3 day). Z-score (y-axis) is the intensity in terms of standard deviations (SD) from the mean. The z-score was calculated by subtracting the mean and dividing by the SD for each probeset. See Additional file 5, Figure S2 for supervised and unsupervised analyses depicted as a heat map.

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Molecular Cancer

ISSN: 1476-4598