Table 3 Additional genes related to apoptosis and the Major Histocompatibility Complex shown to be up-regulated in MSI-H colorectal cancer in comparison to MSS cancers.

Gene name

Fold change

TNF-induced protein

1.9

Tumour necrosis factor receptor superfamily 10d

1.9

Tumour necrosis factor receptor superfamily 9

1.7

Tumour necrosis factor receptor superfamily 10b

1.7

Tumour necrosis factor receptor superfamily 6

1.6

Death-associated protein kinase 1

1.5

DNA fragmentation factor, beta polypeptide (caspase-activated DNase)

1.4

Bcl-2-related protein A1

2.2

Bcl-2/adenovirus E1B 19 kDa interacting protein 3-like

1.8

Bcl-2 antagonist/killer

1.4

Bcl-2 associated athanogene 3

1.4

Bcl-2/adenovirus E1B 19 kDa interacting protein 1

1.2

Baculoviral IAP repeat-containing 3

1.6

Baculoviral IAP repeat-containing 2

1.2

Chemokine (C-X-C motif) receptor 4

1.8

CD27-binding (Siva) protein

1.5

Thioredoxin-like, 32 kDa

1.4

Mitogen-activated protein kinase kinase kinase 5

1.4

Microtubule associated protein tau

1.4

Macrophage erythroblast attacher

1.3

Testis enhanced gene transcript (BAX inhibitor 1)

1.2

Major histocompatibility complex-related genes up-regulated in MSI-H colorectal cancer (P < 0.05, Benjamini and Hochberg False Discovery Rate)

Gene name

Fold change

Major histocompatibility complex, class II, DR alpha

2.0

Major histocompatibility complex, class II, DQ beta 1

1.8

Major histocompatibility complex, class II, DP alpha 1

1.8

H. sapiens HLA-DMA gene

1.7

Major histocompatibility complex, class II, DR beta 1

1.6

Major histocompatibility complex, class II, DR beta 5

1.5

HLA-B associated transcript 1

1.2

Major histocompatibility complex, class I, C

1.2