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Table 2 Expression of necroptotic factors in cancer and its influence on cancer prognosis

From: The role of necroptosis in cancer biology and therapy

Cancer Type

Expression of Necroptotic Factors

The Influence on Prognosis

Reference

Breast Cancer

decreased RIPK3 expression

worse prognosis

[7, 65]

Colorectal Cancer

decreased RIPK3 expression; decreased MLKL expression

reduced DFS and OS; reduced OS

[12, 66, 67]

Acute Myeloid Leukemia

decreased RIPK3 expression

accelerated leukemogenesis and worse survival

[11, 68]

Melanoma

decreased RIPK3 expression;

decreased CYLD expression

not mentioned; enhanced tumor progression and metastasis

[69, 70]

Head and Neck Squamous Cell Carcinoma

decreased RIPK1 expression

enhanced tumorigenesis

[9]

Chronic Lymphocytic Leukemia

decreased CYLD expression

reduced OS

[71]

Glioblastoma

increased RIPK1 expression

worse prognosis

[10]

Lung Cancer

increased RIPK1 expression

promoted oncogenesis

[72]

Pancreatic Cancer

increased expression of RIPK1, RIPK3, FADD and MLKL

promoted oncogenesis

[64, 73]

Gastric Cancer

decreased MLKL expression

reduced OS

[74]

Ovarian Cancer

Decreased MLKL expression

reduced OS

[75]

Cervical Squamous Cell Carcinoma

decreased MLKL expression

reduced OS

[76]