Key Mediators | Function in necroptosis | Inhibitors | Reference |
---|---|---|---|
RIP1 | determining the survival or death of cell; recruiting and activating RIPK3 to form necrosome | nec-1 | |
RIPK3 | interacting with RIPK1 to form necrosome; phosphorylating MLKL | GSK843 and GSK872 | |
MLKL | phosphorylated by RIPK3; oligomerized and translocated to plasma membrane to execute necroptosis | NSA | [16] |
cIAP1/2 | polyubiquitinating RIPK1 to induce NF-κB signaling | smac mimetics | |
CYLD | deubiquitinating RIPK1; promoting “Ripoptosome” formation; promoting necrosome formation | – | [20] |
caspase-8 | cleaving RIPK1 and RIPK3 and activating apoptosis; inhibiting necrosome formation; cleaving CYLD to promote cell survival | zVAD-fmk |