Skip to main content

Table 1 Key mediators in necroptosis and their key function

From: The role of necroptosis in cancer biology and therapy

Key Mediators

Function in necroptosis

Inhibitors

Reference

RIP1

determining the survival or death of cell; recruiting and activating RIPK3 to form necrosome

nec-1

[5, 14, 15]

RIPK3

interacting with RIPK1 to form necrosome; phosphorylating MLKL

GSK843 and GSK872

[15, 16]

MLKL

phosphorylated by RIPK3; oligomerized and translocated to plasma membrane to execute necroptosis

NSA

[16]

cIAP1/2

polyubiquitinating RIPK1 to induce NF-κB signaling

smac mimetics

[14, 19]

CYLD

deubiquitinating RIPK1; promoting “Ripoptosome” formation; promoting necrosome formation

[20]

caspase-8

cleaving RIPK1 and RIPK3 and activating apoptosis; inhibiting necrosome formation; cleaving CYLD to promote cell survival

zVAD-fmk

[21, 23, 24]