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Table 1 Kinases for which phosphorylated target sites were found enriched in Smarcb1 deficient cells. The table depicts kinases, their target residues and relative abundances of the phosphorylated peptide in SMARCB1 proficient/deficient cells (given as the log2 ratio). Kinase targets were defined as described in Materials and methods section. Enrichment for targets was assessed using the GSEA algorithm [53, 54]. Calculated Normalized Enrichment score for kinase targets (KS test): ERK2 = 1.85; ERK1 = 1.66; AKT1 = 1.36; JNK1 = 1.41. Calculated false discovery rate: ERK2 = 0.01; ERK1 = 0.032; AKT1 = 0.223; JNK1 = 0.205

From: Phosphoproteomic analysis reveals Smarcb1 dependent EGFR signaling in Malignant Rhabdoid tumor cells

Kinase

Target

Residue

Log2 (SMARCB1/pMIG)

 

Cdc25b

S351

−1.12

 

Tsc2

S939

−1.65

AKT1

Gsk3b

S9

−1.69

 

Bad

S155

−2.21

 

Rps6

S236

−2.28

 

Acly

S455

−2.31

 

Rell1

T262

−1.20

 

Dcp1a

S335

−1.23

 

Dcp1a

S339

−1.23

 

Junb

S256

−1.35

 

Mybbp1a

S1280

−1.36

 

Ugdh

T474

−1.38

 

Supv3l1

S725

−1.52

ERK2

Rps6ka1

S369

−1.78

 

Dennd4c

S1270

−2.04

 

Ndel1

T219

−2.06

 

Atf2

T53

−2.08

 

Tpx2

T369

−2.39

 

Jun

S246

−2.87

 

Ahnak

S2985

−3.08

 

Ahnak

S4879

−3.39

 

Egfr

T695

−3.99

 

Pxn

S83

−1.18

 

Junb

S256

−1.35

 

Rps6ka1

S369

−1.78

ERK1

Ndel1

T219

−2.06

 

Ranbp3

S58

−2.07

 

Atf2

T53

−2.08

 

Jun

S73

−2.76

 

Jun

S63

−3.69

 

Atf2

T51

−2.08

JNK1

Atf2

T53

−2.08

 

Jun

S73

−2.76

 

Jun

S63

−3.69