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Table 3 Univariate and multivariate analyses of relationship between DSF and TGase 2 expression or clinicopathologic variables by Cox proportional hazard regression model (n = 429)

From: Transglutaminase 2 as an independent prognostic marker for survival of patients with non-adenocarcinoma subtype of non-small cell lung cancer

 

Univariate analysis

Multivariate analysis

 

Hazard ratio

95% CI

p-value

Hazard ratio

95% CI

p-value

Age

1.001

0.986-1.016

0.889

   

Gender

      

   Male

1

1

    

   Female

1.107

0.794-1.542

0.549

   

Histology

  

0.063

  

0.072

   Adenocarcinoma

1

1

 

1

  

   Squamous carcinoma

0.718

0.521-0.991

0.044

0.701

0.487-1.008

0.056

   Others

1.200

0.705-2.042

0.501

1.214

0.710-2.076

0.478

Differentiation

  

0.172

   

   Well

1

1

    

   Moderate

1.424

0.862-2.354

0.168

   

   Poorly

1.699

0.977-2.955

0.061

   

Smoking status

  

0.165

   

   Non-smoker

1

     

   Ex-smoker

1.060

0.720-1.560

0.769

   

   Current smoker

0.766

0.535-1.096

0.144

   

T-Stage

  

0.044

  

0.012

   1

1

1

 

1

1

 

   2

1.323

1 0.879-1.992

0.180

1.463

0.962-2.224

0.069

   3-4

1.898

1.143-3.150

0.013

2.209

1.308-3.731

0.003

N-Stage

  

<0.001

  

<0.001

   0

1

1

 

1

1

 

   1

1.613

1.116-2.330

0.011

1.625

1.118-2.363

0.011

   2-3

2.121

1.459-3.084

<0.001

2.074

1.422-3.025

<0.001

TGase 2 expression

  

0.039

  

0.086

   Negative

1

1

 

1

1

 

   Intermediate

1.230

0.846-1.789

0.277

1.111

0.752-1.642

0.597

   Strong

1.595

1.112-2.287

0.011

1.554

1.046-2.311

0.029

  1. In the multivariate analysis, variables including histology, T-stage and N-stage (those showing p < 0.10 in the univariate analysis) were considered.
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Molecular Cancer

ISSN: 1476-4598